U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 10 results

Status:
US Approved Rx (2014)
First approved in 2007

Class (Stereo):
CHEMICAL (ABSOLUTE)



Fluticasone furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. Fluticasone furoate is a anti-allergic agents that is FDA approved for the treatment of symptoms of seasonal and perennial allergic rhinitis, ast...
Status:
US Approved Rx (2009)
First approved in 1994

Class (Stereo):
CHEMICAL (EPIMERIC)



Budesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, allergic rhinitis and ulcerative colitis. The precise mechanism of corticosteroid actions on inflammation in asthma is not well known. Inflammat...
Status:
US Approved Rx (2000)
First approved in 1994

Class (Stereo):
CHEMICAL (RACEMIC)



Salmeterol is a long-acting beta2-adrenergic agonist. Although beta2-adrenoceptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-adrenoceptors are the predominant receptors in the heart, there are also beta2-adrenocept...
Status:
US Previously Marketed
First approved in 1997

Class (Stereo):
CHEMICAL (ACHIRAL)



Emedastine is an antihistaminic agent, which was approved by FDA for the treatment of allergic conjunctivitis (Emadine brand name). The drug acts selectively on H1 receptors with lower affinity to H2 and H3 subtypes. Emedastine has a relatively unfav...
Status:
US Approved Rx (2015)
First approved in 2015

Class:
PROTEIN

Status:
US Approved Rx (2014)
First approved in 2014

Class:
PROTEIN

Status:
US Approved Rx (2017)
First approved in 2008

Class:
PROTEIN

Status:
US Approved Rx (2017)
First approved in 2013

Class (Stereo):
CHEMICAL (ABSOLUTE)



Vilanterol (INN, USAN) is an ultra-long-acting β2 adrenoreceptor agonist (ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmona...
Status:
US Approved Rx (2015)
First approved in 1996

Class (Stereo):
CHEMICAL (ACHIRAL)



Olopatadine is an antihistamine (as well as anticholinergic and mast cell stabilizer) used to treat itching associated with allergic conjunctivitis (eye allergies). Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 rec...
Status:
US Approved Rx (2025)
First approved in 1994

Class (Stereo):
CHEMICAL (ABSOLUTE)



Tacrolimus, previously known as FK506, is the active ingredient in Prograf. Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506...