Search results for "Drug or Chemical by Structure[C1913]|Organic Chemical[C718]|Lipid[C616]|Steroid Compound" in comments (approximate match)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secr...
Renanolone is a synthetic neuroactive C21 5β-H steroid. It was never used in a clinical setting. The thermogenic and inflammatory responses induced by renanolone were reported to be similar to responses induced generally by appropriate administration...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
2-Methoxyestradiol (2ME2) is a natural metabolite of endogenous estrogen hormone 17β-estradiol in human and devoid of estrogenic activity. It is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis)....
Sulbenox is substituted tetrahydrobenzothiophene derivative patented by American Cyanamid Co as the animal growth-promoting agent. In preclinical studies, Sulbenox found to be an effective growth promoter in sheep, mice, and rats.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Cyclopamine is an inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Cyclopamine is a teratogen isolated from the corn lily that causes usually fatal birth defe...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
27-Hydroxycholesterol (27-HC) is an endogenous oxysterol produced by the enzyme CYP27A1, with multiple biological functions, including acting as a selective estrogen receptor modulator (SERM) and as an agonist of the liver X receptor (LXR). Because ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Glycocholic acid (GCA) is an important metabolite of bile acids, a conjugate of cholic acid with glycine. GCA urine levels are expected to be a specific diagnostic biomarker for hepatocellular carcinoma (HCC). The average GCA concentrations of HCC pa...
Promegestone (R 5020) is a potent progestin devoid of androgenic side-effects and has marked anti-estrogenic activity. Promegestone is an AChR noncompetitive antagonist that may alter AChR function by interactions at the lipid-protein interface. Prom...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Ergosterol was discovered over 100 years ago in the plant pathogenic ergot fungus Claviceps purpurea. Ergosterol is the major fungal membrane sterol that regulates membrane fluidity, plasma membrane biogenesis and function. Antifungal drugs such as A...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was ap...