{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
Search results for zoledronic root_notes_note in Note (approximate match)
Status:
US Previously Marketed
Source:
Paredrinol by Smith Kline & French
(1938)
Source URL:
First approved in 1938
Source:
Paredrinol by Smith Kline & French
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Pholedrine is a hydroxymethylamphetamine. It is a sympathimimetric drug of low toxicity, which is of great value in conditions of hypotonia, collapse, and circulatory depression. Pholedrine was reported on in 1937 by several investigators, who described its vasopressor action in animals as more potent than that of ephedrine. The drug is grouped with hydroxyamphetamine because of its similarity in structure and hemodynamic pattern. Pholedrine, in small doses, potentiates epinephrine, but in large doses blocks its pressor effect. Pholedrine applied as eye-drops produces mydriasis that is greatly attenuated by guanethidine pretreatment and diminished in patients with postganglionic sympathetic nerve lesions. It might be used to diagnose Horner's syndrome.
Status:
US Previously Marketed
Source:
PREDSEM CALCIUM PANTOTHENATE by S. E. Massengill Co.
(1961)
Source URL:
First marketed in 1937
Source:
Calcium pentothate
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Pantothenic acid (known as Vitamin B5) is a water-soluble member of the B-vitamin family that is converted into 4’-phosphopantetheine, which is then converted to co-enzyme A (CoA) via adenosine triphosphate. Pantothenic acid regulates epidermal barrier function and keratinocytes differentiation via CoA metabolism. Pantothenic acid is incorporated into co-enzyme A and protects cells against peroxidative damage by increasing the level of glutathione. A recent feasibility study has also shown that daily oral supplementation of a nutritional agent containing pantothenic acid for 8 weeks was feasible and safe. It was discovered the different pharmacological implementation of pantothenic acid, such as treatment of acne, obesity. Existed some reports, mentioned efficacy using pantothenic acid in systemic lupus erythematosus. Significant reduction in morning stiffness, degree of disability, and severity of pain was reported for persons taking pantothenic acid in case of osteoarthritis and rheumatoid arthritis. Vitamin B5 may increase the effects of a group of drugs called cholinesterase inhibitors, which are used to treat Alzheimer's disease. That might lead to severe side effects.
Status:
US Previously Marketed
Source:
PREDSEM CALCIUM PANTOTHENATE by S. E. Massengill Co.
(1961)
Source URL:
First marketed in 1937
Source:
Calcium pentothate
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Pantothenic acid (known as Vitamin B5) is a water-soluble member of the B-vitamin family that is converted into 4’-phosphopantetheine, which is then converted to co-enzyme A (CoA) via adenosine triphosphate. Pantothenic acid regulates epidermal barrier function and keratinocytes differentiation via CoA metabolism. Pantothenic acid is incorporated into co-enzyme A and protects cells against peroxidative damage by increasing the level of glutathione. A recent feasibility study has also shown that daily oral supplementation of a nutritional agent containing pantothenic acid for 8 weeks was feasible and safe. It was discovered the different pharmacological implementation of pantothenic acid, such as treatment of acne, obesity. Existed some reports, mentioned efficacy using pantothenic acid in systemic lupus erythematosus. Significant reduction in morning stiffness, degree of disability, and severity of pain was reported for persons taking pantothenic acid in case of osteoarthritis and rheumatoid arthritis. Vitamin B5 may increase the effects of a group of drugs called cholinesterase inhibitors, which are used to treat Alzheimer's disease. That might lead to severe side effects.
Status:
US Previously Marketed
Source:
TRIKETOL DEHYDROCHOLIC ACID by ENDO
(1961)
Source URL:
First marketed in 1935
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Sodium dehydrocholate is a hydrocholeretic and is used to study biliary excretion.
Status:
US Previously Marketed
Source:
NEOMERSYL MERSALYL by CENTRAL PHARCA
(1961)
Source URL:
First marketed in 1935
Source:
Salyrgan by Winthrop
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
MERSALYL (Mersal) is an organomercury compound, mercurial diuretics that superseded by safer diuretics such as thiazides, and is hardly used anymore. Due to the idiosyncratic nature of mercury toxicity, the risk of severe disease and sudden death are unpredictable and frequently show no warning signs. Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule. Unfortunately, earlier physicians misconstrued hallmark symptoms of mercury poisoning such as excessive salivation as signs of mercury's efficacy, including up until the early 1960s when the use of mercurial diuretics was halted in medicine.
Status:
US Previously Marketed
Source:
KOAGAMIN PARENTERAL OXALIC ACID by CHATHAM
(1940)
Source URL:
First marketed in 1922
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
US Previously Marketed
Source:
Chlorinated Lime U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Chlorinated Lime U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
CALCIUM CHLORIDE HYDROXIDE HYPOCHLORITE, DIHYDRATE is an inert ingredient in pesticide products.
Status:
US Previously Marketed
Source:
Sodium Hypophosphite U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Hypophosphite U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Hypophosphite is a strong reducing agent, that has been used in the 1850s as a remedy for pulmonary tuberculosis. Hypophosphites were used extensively in pharmaceutical preparations, elixirs, and tonics. Hypophosphite does not appear to have adverse toxicological effects, and the sodium, calcium, and potassium salts are considered GRAS. Hypophosphite use in foods may not be limited to one function. Hypophosphites have been used in foods as antioxidants, stabilizers, meat pickling accelerator, and vegetable protein flow inducer.
Status:
US Previously Marketed
Source:
Sodium Borate U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
BORATE, a salt of boric acid, is used as a food additive in the European Union. This additive is authorized for use as preservatives of sturgeon eggs (caviar).
Status:
US Previously Marketed
Source:
Gallic Acid U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Gallic acid is a polyphenol found in a variety of foods and herbs. Several studies have shown thta gallic acid has neuroprotective and anti-oxidant properties and can be a promising candidate for the treatment of cancer, cardiovascular diseases, neurodegenerative disorders, fatty liver disease and many others. Gallic acid acts by protecting cells against oxidative damage caused by reactive species often encountered in biological systems including, hydroxyl, superoxide and peroxyl and the non-radicals, hydrogen peroxide and hypochlorous acid. However, its ability to induce apoptosis, is mainly associated with its prooxidant, rather than antioxidant behavior.