Ethyl dirazepate is an anticonvulsant compound.

Proadifen is an inhibitor of drug metabolism and cytochrome P450 enzyme system activity. It stimulated the release of prostacyclin (PGI2) from the rabbit aorta, bovine aorta and human umbilical vein in vitro, but had no effect on cultured smooth muscle from the bovine aortic media. In human platelets, proadifen inhibited prostaglandin and thromboxane production induced by A23187, thrombin, and ADP. Proadifen might thus constitute the prototype of a new class of antiplatelet drugs.

Pravadoline is the anti-nociceptive agent, which has analgesic efficacy against postoperative pain in humans. Pravadoline inhibits the enzyme cyclooxygenase, but in contrast to cyclooxygenase-inhibiting NSAIDs does not produce gastrointestinal irritation. Pravadoline inhibited the synthesis of prostaglandins in mouse brain both in vitro and ex vivo. Pravadoline demonstrated only weak anti-inflammatory activity relative to its anti-nociceptive potency. Single doses of pravadoline were safe and effective in humans, without serious adverse events. Single oral administration of pravadoline maleate induced acute tubular necrosis in male and female beagle dogs.

Dofamium is the antiseptic agent. It was used for the water sterilization.

Oxabrexine was developed as a diuretic; however, this compound has never been marketed. Information about the current use of this compound is not available.

Information in the scientific papers related to the biological and/or pharmacological application of amindocate is absent.

Denaverine is a benzilacid derivative. It is a phenobarbital-type microsomal enzyme inducer. Denaverine has a relaxing effect on the prepartum uterus and provides an increased flexibility of the soft birth canal. In addition, it has a surface anaestetic effect and an anticonvulsive effect as well as a slightly tranquilizing and antipyretic effect. In veterinary medicine denaverine hydrochloride is used to regulate myometrial contractions during parturition. It is a regularly used substance in obstetrics in veterinary medicine in many European countries.

Cloroqualone is an analog of Methaqualone developed in 1980. Cloroqualone possesses a weaker sedative effect than Methaqualone. It was marketed in France and some other European countries either alone or in combination with other ingredients as cough medicine.

Cloxacepride is an amide of the dopamine antagonist metoclopramide. It was discovered in the 1980s by Merkle and Panlabs and was found to possess anti-allergic properties. Cloxacepride demonstrated activity in a rat Passive Cutaneous Anaphylaxis (PCA) model after oral administration. Cloxacepride did not protect against histamine-induced anaphylaxis in guinea pigs, thus it was concluded that the effect of cloxacepride is not mediated by histamine receptors. In experiments with human mast cells from adenoidal tissues, cloxacepride at concentrations 10-100 uM significantly inhibited concanavalin A (con A) induced histamine release. At higher concentrations, cloxacepride caused the release of histamine. These findings indicate that cloxacepride acts through calmodulin antagonism.