14-deoxy-11,12-dehydroandrographolide (DAP), a major component of the traditional Chinese medicine Andrographis paniculata, exerted the antiviral and anti-inflammatory activities in vitro against H5N1 influenza A virus infections. DAP strongly inhibited H5N1 replication by reducing the production of viral nucleoprotein (NP) mRNA, NP and NS1proteins, whereas DAP had no effect on the absorption and release of H5N1 towards/from A549 cells. DAP also effectively restrained the nuclear export of viral ribonucleoprotein (vRNP) complexes.

AS-252424 is a potent and selective PI 3-kinase p110γ inhibitor. It is known, that the p110γ isoform has partially overlapping roles with p110δ in B cell development, but little is known about its role in B cell function. Recently was found, that the AS-252424 had no significant impact on B cell responses.