Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H28O4 |
| Molecular Weight | 332.4339 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CCC(=C)[C@@H](\C=C\C3=CCOC3=O)[C@]1(C)CC[C@@H](O)[C@@]2(C)CO
InChI
InChIKey=XMJAJFVLHDIEHF-CRBRZBHVSA-N
InChI=1S/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16+,17-,19+,20+/m1/s1
14-deoxy-11,12-dehydroandrographolide (DAP), a major component of the traditional Chinese medicine Andrographis paniculata, exerted the antiviral and anti-inflammatory activities in vitro against H5N1 influenza A virus infections. DAP strongly inhibited H5N1 replication by reducing the production of viral nucleoprotein (NP) mRNA, NP and NS1proteins, whereas DAP had no effect on the absorption and release of H5N1 towards/from A549 cells. DAP also effectively restrained the nuclear export of viral ribonucleoprotein (vRNP) complexes.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes. | 2011 Dec |
|
| Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells. | 2012 Feb |
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5S0X4YZJ0E
Created by
admin on Sat Dec 16 10:04:50 GMT 2023 , Edited by admin on Sat Dec 16 10:04:50 GMT 2023
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42895-58-9
Created by
admin on Sat Dec 16 10:04:50 GMT 2023 , Edited by admin on Sat Dec 16 10:04:50 GMT 2023
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5708351
Created by
admin on Sat Dec 16 10:04:50 GMT 2023 , Edited by admin on Sat Dec 16 10:04:50 GMT 2023
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SUBSTANCE RECORD
