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Restrict the search for
chlorphenesin carbamate
to a specific field?
Status:
US Previously Marketed
Source:
DAKLINZA by BRISTOL-MYERS SQUIBB
(2015)
Source URL:
First approved in 2015
Source:
DAKLINZA by BRISTOL-MYERS SQUIBB
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Daclatasvir (BMS-790052) is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 3 infection. Daclatasvir prevents RNA replication and virion assembly by binding to NS5A, a nonstructural phosphoprotein encoded by HCV. Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and membranes required for virion replication complex assembly.
Status:
US Previously Marketed
Source:
ZONTIVITY by KEY THERAP
(2014)
Source URL:
First approved in 2014
Source:
ZONTIVITY by KEY THERAP
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Vorapaxar is a tricyclic himbacine-derived oral thrombin receptor antagonist that acts by reversible inhibition of the protease-activated receptor-1 (PAR-1). PAR-1 is expressed on platelets and its inhibition prevents platelets from aggregation. Vorapaxar is approved by FDA and is indicated for the reduction of recurring thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease. Vorapaxar at the same time may cause bleeding complications including intracranial haemorrhage (ICH), when compared to standard therapy alone. That is why Vorapaxar is contraindicated in patients with prior stroke, transient ischemic attack and ICH.