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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Piceatannol (3,3′,4,5′-tetrahydroxy-trans-stilbene; PIC) is a naturally occurring stilbene present in diverse plant sources. Piceatannol is a hydroxylated analog of resveratrol and produced from resveratrol by microsomal cytochrome P450 1A11/2 and 1B1 activities. Like resveratrol, Piceatannol has a broad spectrum of health beneficial effects, many of which are attributable to its antioxidative and anti-inflammatory activities. Piceatannol exerts anticarcinogenic effects by targeting specific proteins involved in regulating cancer cell proliferation, survival/death, invasion, metastasis, angiogenesis, etc. in the tumor microenvironment. Piceatannol also has other health promoting and disease preventing functions, such as anti-obese, antidiabetic, neuroprotective, cardioprotective, anti-allergic, anti-aging properties. A comprehensive review of PIC concludes that the compound has the health promoting and disease preventive potential. However, low water-solubility and bioavailability of PIC limit its pharmaceutical application and also use in functional foods. In this context, it is noticeable that beta-cyclodextrin was found to improve the bioavailability, the solubility and the stability of Piceatannol.
Fluorodopa (FDOPA) is a fluorinated analog of levodopa (L-DOPA) used to assess the nigrostriatal dopamine system in vivo with positron emission tomography (PET) in the form of fluorine-18 isotopologue. It is often used for studies requiring repeated imaging, including examinations over the course of a disease and/or the effect of treatment. 18F-labeled FDOPA, which was primarily developed to measure dopamine synthesis in the basal ganglia, has also increasingly been used as a tracer for brain tumor imaging. FDOPA is currently approved for characterization of presynaptic dopaminergic activity in patients with Parkinsonian syndromes in the United States and Western Europe. The increased uptake of MET, FET and FDOPA in gliomas and brain metastases appears to be caused predominantly by increased transport via the amino acid transport system L for large neutral amino acids namely the subtypes LAT1 and LAT2.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
