U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 611 - 620 of 651 results

Status:
Investigational
Source:
NCT04231266: Phase 2 Interventional Active, not recruiting GNE Myopathy
(2022)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

N-acetylmannosamine (ManNAc), a hexosamine monosaccharide, is the first committed biological precursor of Neu5Ac. N-acetylmannosamine is being investigated as a potential treatment for GNE myopathy. N-acetylmannosamine has being reported to improve the cognitive function in aged animals. It has potential therapeutic application for cognitive dysfunction. N-acetylmannosamine is under investigation for GNE myopathy.
Status:
Investigational
Source:
JAN:SODIUM ACENEURAMATE [JAN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Sodium aceneuramate is a sodium salt of aceneuramic acid (sialic acid). It is an effective inhalant expectorant. Inhalation of sodium aceneuramate repaired inflammation in the airway, and caused bronchitic rabbits to produce sputa with a low viscosity, similar to normal air-way secretions. Sodium aceneuramate protected the mucociliary transport impaired bycigarette smoke in a dose-dependent manner. The results suggest that sodium aceneuramate may participate in the defense mechanism in the airway against irritant gases. Sodium aceneuramate inhibited bronchial anaphylaxis and the release of histamine into bronchoalveolar lavages. Sodium aceneuramate has an action which elevates the viscoelasticity of secretions in the respiratory tract.
Status:
Designated
Source:
EU-Orphan Drug:EU/3/16/1654
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Showing 611 - 620 of 651 results