N-{5-[4-(1-Acetyl-7-indolinylamino)-5-chloro-2-pyrimidinylamino]-2-{[2-(dimethylamino)ethyl]-N-methylamino}-4-methoxyphenyl}acrylamide

Approval Year

Substance Class	Concept
Record UNII	FV24A4KAF3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-Propenamide, N-[5-[[4-[(1-acetyl-2,3-dihydro-1H-indol-7-yl)amino]-5-chloro-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-

Preferred Name

English

N-{5-[4-(1-Acetyl-7-indolinylamino)-5-chloro-2-pyrimidinylamino]-2-{[2-(dimethylamino)ethyl]-N-methylamino}-4-methoxyphenyl}acrylamide

Systematic Name

English

Code System Code Type Description

CAS

2900376-84-1

Created by admin on Wed Apr 02 20:24:15 GMT 2025 , Edited by admin on Wed Apr 02 20:24:15 GMT 2025

PRIMARY

FDA UNII

FV24A4KAF3

Created by admin on Wed Apr 02 20:24:15 GMT 2025 , Edited by admin on Wed Apr 02 20:24:15 GMT 2025

PRIMARY

PUBCHEM

167455052

Created by admin on Wed Apr 02 20:24:15 GMT 2025 , Edited by admin on Wed Apr 02 20:24:15 GMT 2025

PRIMARY

This is a non-substance concept

Related Record Type Details


					FV24A4KAF3

N-{5-[4-(1-Acetyl-7-indolinylamino)-5-chloro-2-pyrimidinylamino]-2-{[2-(dimethylamino)ethyl]-N-methylamino}-4-methoxyphenyl}acrylamide

ACTIVE MOIETY

Comments:

The mode of action of YH42946 is to inhibit the phosphorylation of HER2 tyrosine kinase domain harboring HER2-exon20 insertion and subsequently inhibit the downstream signaling such as AKT and MEK, which results in the inhibitory effects of cell proliferation

Amount: