U.S. Department of Health & Human Services
National Institutes of Health
NCATS
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Development Status
Other
5,096
Investigational
784
Possibly Marketed Outside US
383
US Approved Rx
300
US Previously Marketed
77
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Primary Target
Dopamine D2 receptor
42
Histamine H1 receptor
34
Serotonin 2a (5-HT2a) receptor
33
Acetylcholinesterase
25
DNA topoisomerase I
23
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Highest Phase
Approved
397
Phase II
78
Phase III
49
Phase I
40
Not Provided
27
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Approval Year
Unknown
6,109
2013
28
1996
25
1921
23
2020
20
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Condition
Unknown
127
Cancer
61
Depression
39
Schizophrenia
37
Alzheimer’s disease
34
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Treatment Modality
Primary
598
Curative
110
Palliative
73
Preventing
44
Diagnostic
29
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CNS Activity
CNS Active
229
CNS Penetrant
158
CNS Non-penetrant
60
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Originator
Eli Lilly
23
Bayer
21
GlaxoSmithKline
21
Merck
18
Bristol-Myers Squibb
12
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Substance Class
Chemical
5,843
Protein
354
Structurally Diverse
318
Mixture
85
Polymer
53
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INN Stem
Monoclonal antibodies(-mab)
14
Tyrosine-kinase inhibitors(-tinib)
12
Chemical substance(-ine)
8
Gene Therapy vectors(-vec)
6
Antiviral drug(-vir)
4
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GInAS Tag
KEW
2
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Code System
FDA UNII
6,700
CAS
5,943
PUBCHEM
5,653
EPA CompTox
3,622
SMS_ID
1,312
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Protein Type
MONOCLONAL ANTIBODY
42
MONOCLONAL ANTIBODY CONJUGATE
29
RECEPTOR
27
BISPECIFIC ANTIBODY
22
ENZYME
20
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ATC Level 1
NERVOUS SYSTEM
44
ALIMENTARY TRACT AND METABOLISM
34
SENSORY ORGANS
31
ANTIINFECTIVES FOR SYSTEMIC USE
29
DERMATOLOGICALS
27
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ATC Level 2
OPHTHALMOLOGICALS
30
ANTINEOPLASTIC AGENTS
18
PSYCHOLEPTICS
17
ANTIBACTERIALS FOR SYSTEMIC USE
15
PSYCHOANALEPTICS
15
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ATC Level 3
ANTIDEPRESSANTS
13
ANTIINFECTIVES
12
ANTIPSYCHOTICS
12
OTHER ANTINEOPLASTIC AGENTS
11
STOMATOLOGICAL PREPARATIONS
7
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ATC Level 4
Non-selective monoamine reuptake inhibitors
13
Antibiotics
8
Other antineoplastic agents
7
Antiinfectives
6
Diazepines, oxazepines, thiazepines and oxepines
5
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Substance Form
Principal Form
5,908
Salts, Hydrates, Esters, etc.
792
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