Methyl-1-testosterone(M1T)(17alpha-hydroxy-17-methyl- 5-androst-1-en-3-one) is a new designer steroid that is most likely produced to circumvent the legal restrictions. It is advertised to be highly anabolic and moderately androgenic and not convertible to estrogens. However, in scientific literature, it was reported to show anabolic properties of 25% and androgenic properties of 50% compared with testosterone propionate after im injection in castrated rats. In February 2006, Health Canada (Federal Department) warned consumers not to use M1T-containing products because of potentially serious health risks such as liver disorders and hardening of the arteries. Since 2006, M1T is explicitly listed on the World Anti-Doping Agency list of prohibited substances, and therefore, its use by athletes is prohibited.

Hordenine is a natural Phenethylamine compound that occurs in a number of different plants, but especially barley grass. It is structurally similar to the amino acid Tyramine. It antagonized D2-mediated beta-arrestin recruitment indicating functional selectivity. Hordenine inhibited melanogenesis by suppressing cAMP production, which is involved in the expression of melanogenesis-related proteins. Hordenine may be an effective inhibitor of hyperpigmentation. Hordenine is an indirectly acting adrenergic drug. It liberates norepinephrine from stores. In isolated organs and those structures with reduced epinephrine contents, the hordenine-effect is only very poor. Experiments in intact animals (rats, dogs) show that hordenine has a positive inotropic effect upon the heart, increases systolic and diastolic blood pressure, peripheral blood flow volume, inhibits gut movements but has no effect upon the psychomotorical behavior of mice. Hordenine is considered to be generally very safe and well-tolerated in healthy adults. Hordenine is a nootropic compound that works equally well for cognitive enhancement and athletic performance.