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Search results for norethindrone root_Display\ Name in Display Name (approximate match)
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Allopregnan-3α-ol-20-one acetate (5α-Pregnan-3β-ol-20-one 3β-acetate) is a derivative of neurosteroid Allopregnanolone. Allopregnan-3α-ol-20-one acetate is an allosteric modulator of inhibitory γ-aminobutyric acid (GABA-A) receptors on neural stem cells and other cell types in the brain. Allopregnanolone acetate exerted moderate antidystonic effects and provoked a moderately reduced locomotor activity in animal models. Metabolic transformation of Allopregnan-3α-ol-20-one acetate leads Allopregnanolone. Allopregnanolone is in phase III trials for the treatment of super-refractory status epilepticus (SRSE) and postpartum depression, but Allopregnan-3α-ol-20-one acetate was never tested in clinical trials.