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Radioactive ZN-65 was used as a diagnostic compound. It was used to determine the intracellular distribution of zinc in normal and tumor tissues. It was found that Zn was in nuclear, mitochondrial and supernatant fractions of mammary tumors and livers. In addition, some part of ZN-65 was bound to protein and could not be removed by exchange or by combination with ethylenediaminetetraacetic acid.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
17β-Carboxyandrost-4-en-3-one is an intermediate in the synthesis of the drugs Dutasteride (D735000) and Finasteride. 17β-Carboxyandrost-4-en-3-one shows weak inhibition of Steroid 5-alpha-reductase and Androgen Receptor antagonism.
