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4-Hydroxy-4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl-2-cyclohexen-1-one, (4S,3R)-(E)-(±)- (Blumenol A) is a major secondary metabolite initially isolated from the leaves of Annona glabra L. (Annonaceae), commonly known as pond apple, which is a tropical tree distributed mainly in the Americas and in Southeast Asia, and used in traditional medicine as an insecticide and a parasiticide. Blumenol A was reported to display inhibitory activity against a panel of human solid tumor cell lines
4-Hydroxy-4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl-2-cyclohexen-1-one, (4S,3R)-(E)-(±)- (Blumenol A) is a major secondary metabolite initially isolated from the leaves of Annona glabra L. (Annonaceae), commonly known as pond apple, which is a tropical tree distributed mainly in the Americas and in Southeast Asia, and used in traditional medicine as an insecticide and a parasiticide. Blumenol A was reported to display inhibitory activity against a panel of human solid tumor cell lines
Homoveratrylamine (3,4-dimethoxyphenethylamine, DMPEA) is an analog of the major neurotransmitter dopamine where 3- and 4- position hydroxyl groups are replaced with methoxy groups. DMPEA is a metabolite of dopamine and is reported to be produced at elevated levels in patients with schizophrenia and Parkinson's disease. DMPEA inhibited monoamine oxidase and demonstrated no peripheral and central antidopaminergic activity in vivo.
