U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 431 - 440 of 13268 results

Status:
Investigational
Source:
INN:zegruvirimat [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:carfloglitazar [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
INN:tambiciclib [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:fepromide [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

FEPRADINOL is an antiarrhythmic agent.
Status:
Investigational
Source:
INN:perastine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Perastine is an antihistaminic agent.
Status:
Investigational
Source:
NCT03359785: Phase 2 Interventional Completed Schizophrenia
(2018)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:ciprokiren
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Ciprokinen is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of ciprokinen lead to a reduction in arterial blood pressure. Development of ciprokinen was discontinued at a preclinical stage.
Status:
Investigational
Source:
INN:idoxifene
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Idoxifene (also known as CB 7432), a novel selective estrogen receptor modulator, is originally discovered at the CRC Centre for Cancer Therapeutics, Institute. This drug participated in clinical trials phase II in patients with locally advanced/metastatic breast cancer resistant to tamoxifen. In addition, in phase III in postmenopausal women after one year of idoxifene treatment. However, both studies were discontinued because of insufficient effectiveness.
Status:
Investigational
Source:
NCT01435096: Phase 1 Interventional Completed Malignant Solid Tumour
(2004)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Elomotecan (BN 80927), a homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation. It potently inhibits proliferation of human tumor cells in vitro and in vivo. Elomotecan was being developed for the treatment of solid tumors.
Status:
Investigational
Source:
INN:etaminile [INN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Etaminile is an antitussive agent.