Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H32ClN3O4 |
| Molecular Weight | 522.035 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@@]1(O)CC(=O)OCC2=C1C=C3N(CC4=C3N=C5C=C(Cl)C(C)=CC5=C4CN6CCC(C)CC6)C2=O
InChI
InChIKey=KAQREZSTQZWNAG-GDLZYMKVSA-N
InChI=1S/C29H32ClN3O4/c1-4-29(36)12-26(34)37-15-21-22(29)10-25-27-20(14-33(25)28(21)35)19(13-32-7-5-16(2)6-8-32)18-9-17(3)23(30)11-24(18)31-27/h9-11,16,36H,4-8,12-15H2,1-3H3/t29-/m1/s1
| Molecular Formula | C29H32ClN3O4 |
| Molecular Weight | 522.035 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II. | 1999 Sep 6 |
|
| The homocamptothecin, BN 80927, is a potent topoisomerase I poison and topoisomerase II catalytic inhibitor. | 2000 |
|
| The dual topoisomerase inhibitor, BN 80927, is highly potent against cell proliferation and tumor growth. | 2000 |
|
| BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo. | 2004 Jul 15 |
Patents
Sample Use Guides
Phase I study. Elomotecan was administered as a 30-min intravenous infusion at doses ranging from 1.5 to 75 mg once every 3 weeks to 56 patients with advanced solid tumors. Plasma concentration data and adverse effects were modeled using the population approach.
Route of Administration:
Intravenous
The antiproliferative activity of elomotecan (BN 80927) was determined on various human tumor cell lines from a diverse set of target organs, including leukemia and solid tumors (colon, prostate, ovary, lung, bladder, and breast cell lines). BN80927 was an antiproliferative agent on all of the cell lines tested. On this set of cell lines, BN80927 has IC50 values 2–81 nM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:03:22 GMT 2023
by
admin
on
Sat Dec 16 16:03:22 GMT 2023
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| Record UNII |
44KA9Q75GT
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C2843
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DTXSID50176608
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8589
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CHEMBL2107746
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C87275
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100000174924
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44KA9Q75GT
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220998-10-7
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216301
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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