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Restrict the search for
m nalidixic acid
to a specific field?
Status:
US Previously Marketed
Source:
PREDSEM CALCIUM PANTOTHENATE by S. E. Massengill Co.
(1961)
Source URL:
First marketed in 1937
Source:
Calcium pentothate
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Pantothenic acid (known as Vitamin B5) is a water-soluble member of the B-vitamin family that is converted into 4’-phosphopantetheine, which is then converted to co-enzyme A (CoA) via adenosine triphosphate. Pantothenic acid regulates epidermal barrier function and keratinocytes differentiation via CoA metabolism. Pantothenic acid is incorporated into co-enzyme A and protects cells against peroxidative damage by increasing the level of glutathione. A recent feasibility study has also shown that daily oral supplementation of a nutritional agent containing pantothenic acid for 8 weeks was feasible and safe. It was discovered the different pharmacological implementation of pantothenic acid, such as treatment of acne, obesity. Existed some reports, mentioned efficacy using pantothenic acid in systemic lupus erythematosus. Significant reduction in morning stiffness, degree of disability, and severity of pain was reported for persons taking pantothenic acid in case of osteoarthritis and rheumatoid arthritis. Vitamin B5 may increase the effects of a group of drugs called cholinesterase inhibitors, which are used to treat Alzheimer's disease. That might lead to severe side effects.
Status:
US Previously Marketed
Source:
TRIKETOL DEHYDROCHOLIC ACID by ENDO
(1961)
Source URL:
First marketed in 1935
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Sodium dehydrocholate is a hydrocholeretic and is used to study biliary excretion.
Status:
US Previously Marketed
Source:
NEOMERSYL MERSALYL by CENTRAL PHARCA
(1961)
Source URL:
First marketed in 1935
Source:
Salyrgan by Winthrop
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
MERSALYL (Mersal) is an organomercury compound, mercurial diuretics that superseded by safer diuretics such as thiazides, and is hardly used anymore. Due to the idiosyncratic nature of mercury toxicity, the risk of severe disease and sudden death are unpredictable and frequently show no warning signs. Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule. Unfortunately, earlier physicians misconstrued hallmark symptoms of mercury poisoning such as excessive salivation as signs of mercury's efficacy, including up until the early 1960s when the use of mercurial diuretics was halted in medicine.
Status:
US Previously Marketed
Source:
PENTOTHAL by ABBOTT
(1959)
Source URL:
First marketed in 1934
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Sodium thiopental (also known as Sodium Pentothal, thiopental) was discovered in 1930s by investigators working for Abbott Laboratories. Thiopental sodium was used for the induction of general anesthesia and is used as an adjunct to provide hypnosis during balanced anesthesia with other anesthetic agents, including analgesics and muscle relaxants. Thiopental sodium was also used as an adjunct for control of convulsive disorders of various etiology, including those caused by local anesthetics. Finally, thiopental sodium had been used to reduce the intracranial pressure in patients with increased intracranial pressure, if controlled ventilation is provided. Nevertheless, these prescriptions of drug were discontinued. In addition, this drug was banned for use in US executions. Thiopental sodium acts through the CNS with particular activity in the mesencephalic reticular activating system. It was shown, that mechanism of action of sodium thiopental via GABAA receptor. Thiopental binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Status:
US Previously Marketed
First marketed in 1933
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Hexobarbital or hexobarbitone, (sold both in acid and sodium salt, brand name Evipan, and Tobinal), is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of effects and short duration of action. It was also used to murder women prisoners at Ravensbruck Concentration Camp. Modern barbiturates (such as Thiopental) has largely supplanted the use of hexobarbital as an anesthetic, as they allow for better control of the depth of anesthesia. Hexobarbital is still used in some scientific research. Hexobarbital binds at a distinct binding site associated with a Cl- ionophore at the GABA-A receptor, increasing the duration of time for which the Cl- ionophore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Status:
US Previously Marketed
Source:
SECOBARBITAL SODIUM by WEST WARD
(1982)
Source URL:
First marketed in 1929
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Secobarbital sodium, a barbiturate, is FDA approved for the treatment of insomnia and for pre-anesthetic use. This drug binds at a distinct site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Adverse reactions are drowsiness, lethargy, hangover, paradoxical excitement in elderly patients, somnolence. Rifampin may decrease secobarbital levels by increasing metabolism.
Status:
US Previously Marketed
Source:
Genoscopolamine
(1926)
Source URL:
First marketed in 1926
Class (Stereo):
CHEMICAL (EPIMERIC)
Conditions:
Scopolamine Aminoxide Hydrobromide is one of Scopolamine metabolites, with remarkable Acetylcholinesterase inhibitory activity.
Status:
US Previously Marketed
Source:
KOAGAMIN PARENTERAL OXALIC ACID by CHATHAM
(1940)
Source URL:
First marketed in 1922
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
US Previously Marketed
Source:
KOAGAMIN PARENTERAL OXALIC ACID by CHATHAM
(1940)
Source URL:
First marketed in 1922
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
US Previously Marketed
Source:
KOAGAMIN PARENTERAL OXALIC ACID by CHATHAM
(1940)
Source URL:
First marketed in 1922
Class (Stereo):
CHEMICAL (ACHIRAL)
