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Search results for vitamin root_Display\ Name in Display Name (approximate match)
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
COMPOUND401 is the reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). COMPOUND401 exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Compound401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts.