U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 38191 - 38200 of 39585 results

Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. It is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. It inhibits cyclooxygenases and shows little anti-inflammatory activity. Like many old and approved substances after almost 100 years of use, antipyrine has been associated with some serious side effects, namely agranulocytosis and shock reactions.
Status:
US Previously Marketed
Source:
55 FR 33254 corn/callus remover phenoxyacetic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Phenoxyacetic acid is found in cocoa and cocoa products. Phenoxyacetic acid is a flavouring ingredient. Phenoxyacetic acid is on the FDA list of approved food additives (PART 172 - FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION; Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants.). Research has shown that Phenoxyacetic acid induced hematopoietic cell proliferation, providing potential for oral therapeutics which stimulate proliferation of hematopoietic cells of multiple lineages, as well as inducing fetal globin, important for therapy of hemoglobinopathies.
Status:
US Previously Marketed
Source:
55 FR 33254 corn/callus remover phenoxyacetic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Phenoxyacetic acid is found in cocoa and cocoa products. Phenoxyacetic acid is a flavouring ingredient. Phenoxyacetic acid is on the FDA list of approved food additives (PART 172 - FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION; Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants.). Research has shown that Phenoxyacetic acid induced hematopoietic cell proliferation, providing potential for oral therapeutics which stimulate proliferation of hematopoietic cells of multiple lineages, as well as inducing fetal globin, important for therapy of hemoglobinopathies.
Status:
US Previously Marketed
Source:
64 FR 27682 sunscreen sodium 3, 4-dimethylphenyl-glyoxylate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Sodium 3,4-dimethylphenylglyoxylate is a topical analgesic, sunscreen ingredient, UV-B absorber, FDA approved.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(8)(i) digestive aid bismuth sodium tartrate
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Bismuth tartrate was used for the treatment of syphilis. There are death reports associated with bismuth compounds usage in syphilis treatment.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(8)(i) digestive aid bismuth sodium tartrate
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Bismuth tartrate was used for the treatment of syphilis. There are death reports associated with bismuth compounds usage in syphilis treatment.
Status:
Possibly Marketed Outside US
Source:
CFR:21 CFR 331.11
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

D-(-)-tartaric acid is isomer of tartaric acid, that industrially produced in the largest amounts. D-(-)-Tartaric acid may be used in the preparation of enantiospecific homochiral cis-4-formyl β-lactams. It may also be used as a starting material in the synthesis of D-erythro-sphingosine and L-lyxo-phytosphingosine. D-(-)-tartaric acid is widely used as an acidizing agent for beverages and other foods, and this use is similar to citric acid. Tartaric acid can be used as an acid dye mordant when it is combined with tannin. It is also used for some development and fixing operations in the photographic industry. D-(-)-Tartaric Acid is used in the preparation of synthetic analgesics. Tartaric acid is metabolically inert in the human body. When taken by mouth, only about 20% of ingested tartrate is eliminated in the urine; the remainder is not absorbed as such since it is destroyed in the intestinal tract by bacterial action. Sodium tartrate in daily doses of up to 10 or even 20 g has been used in medical practice as a laxative.

Showing 38191 - 38200 of 39585 results