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Restrict the search for
bempedoic acid
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There are no information about AMMONIUM COBALTOUS PHOSPHATE, except is mentioned, that it was toxic.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Dehydroabietic acid (DHA or DAA), a diterpene, is obtained from Commiphora oppbalsamum. DHA has potential as treatment for obesity and metabolic syndrome, obese diabetic KK-Ay mice treated with DHA showed decreased plasma glucose, insulin, and triglyceride levels. It has been reported that DHA inhibits the production of proinfammatory mediators such as TNF-α in macrophages and adipocytes and causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Also was shown, that DHA could reverse several cell responses stimulated by TNF-α, including the activation of FOXO1 and the TGF-β1/Smad3 signaling pathway. Thus, DAA could be useful in improving the diabetic wound healing.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
NO-711 (aka NNC-711) is an anticonvulsant under development by Novo Nordisk. It acts as a gamma-aminobutyric acid (GABA) uptake inhibitor by inhibiting GAT-1. It has been investigated as a potential therapeutic agent for a number of cognitive disorders, as well as the potential to improve normal cognitive functions.
