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Restrict the search for
adenosine
to a specific field?
Status:
Investigational
Source:
INN:pozetaldogene ormesparvovec [INN]
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Investigational
Source:
INN:ristoglogene autogetemcel [INN]
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Investigational
Source:
INN:rivunatpagene miziparvovec [INN]
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Investigational
Source:
NCT04140539: Phase 2/Phase 3 Interventional Withdrawn Severe Combined Immunodeficiency Due to ADA Deficiency
(2019)
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Other
Class:
STRUCTURALLY DIVERSE
Status:
First approved in 2004
Source:
21 CFR 352
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Investigational
Source:
NCT04686175: Phase 1/Phase 2 Interventional Completed Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency
(2021)
Source URL:
Class:
CONCEPT
Status:
Investigational
Source:
NCT02754141: Phase 1/Phase 2 Interventional Completed Malignant Solid Tumor
(2016)
Source URL:
Class:
CONCEPT
Status:
US Approved Rx
(2008)
Source:
NDA022161
(2008)
Source URL:
First approved in 2008
Source:
NDA022161
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Regadenoson (Lexiscan), a low affinity agonist of the A2A adenosine receptor, increases coronary blood flow (CBF) and mimics the increase in CBF caused by exercise. Myocardial uptake of the radiopharmaceutical is proportional to CBF creating the contrast required to identify stenotic coronary arteries. It is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. The most common adverse reactions to Lexiscan are dyspnea, headache, flushing, chest discomfort, dizziness, angina pectoris, chest pain, and nausea. Methylxanthines, e.g., caffeine and theophylline, may interfere with the activity of Lexiscan. Aminophylline may be used to attenuate severe and/or persistent adverse reactions to Lexiscan.
Status:
US Approved Rx
(2005)
Source:
ANDA077133
(2005)
Source URL:
First approved in 1976
Source:
VIRA-A by PARKEDALE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Vidarabine or 9-β-D-arabinofuranosyladenine (ara-A, trade name Vira-A) is a synthetic purine nucleoside analog with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analog. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
