U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 331 - 340 of 3145 results

Status:
Investigational
Source:
INN:clonitazene [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Clonitazene is a synthetic opioid analgesic, structurally related to etonitazene. In the USA clonitazene is a schedule I narcotic controlled substance.
Status:
Investigational
Source:
NCT00623363: Phase 2 Interventional Completed Parkinson's Disease
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Piclozotan (SUN N4057) is a 1,4-benzoxazepine derivative that exhibits sub-nanomolar affinity at serotonin 1A receptor with good selectivity over dopamine D2 and α1-adrenoceptors. Piclozotan reduced levodopa-induced forelimb hyperkinesia by 55% and 69%, respectively, at 1h relative to the control. Piclozotan significantly lengthened the duration of rotational behavior by 26% versus the control and attenuated the increase in striatal levodopa-derived extracellular dopamine levels. Piclozotan, a serotonin 1A agonist, can improve motor complications in patients with advanced Parkinson's disease. Piclozotan has been shown to be neuroprotective against ischemic neuronal damage in animal models. Piclozotan had been in phase II for the treatment of stroke. However, this research has been discontinued.
Status:
Investigational
Source:
INN:iolidonic acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Iolixanic Acid is triiodophenoxyalkoxyalkanoic acid derivative patented by Bracco Industria Chimica S.p.A. as diagnostic agent for cholecystography.
Status:
Investigational
Source:
INN:ioseric acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Ioseric Acid is triiodoisophthalamic acid derivative patented by Schering A.-G. as x-ray contrast media
Status:
Investigational
Source:
INN:iotetric acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iotetric Acid is triiodobenzoic acid derivative with potential application as neutrophil imaging in diagnosis of cystic fibrosis.
Status:
Investigational
Source:
INN:persilic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Persilic acid is a virucide, hemostatic, capillary protective agent. 0.1% aqueous solution of K salt is used as a fluorescent acid-base indicator.
Status:
Investigational
Source:
INN:dichloroxylenol [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dichloroxylenol is a bactericide, preservative and deodorant. It is often used in the preparation of antiseptic and deodorant lotions and bath preparations. Dichloroxylenol also showed slightly greater activity against S. aureus Oxoid 701/1 Lot 610254 than against Escherichia coli and Salmonella typhi, indicating a probable role for cell wall in the susceptibility of bacteria to dichloroxylenol. The efficacy of either povidone-iodine (Betadine) or dichloroxylenol (Septocid) intrauterine infusions on the treatment of endometritis and/or cervicitis in cows was examined. The recovery and conception rates obtained after Betadine treatment were better than those obtained after Septocid. Moreover, healthy cows and those inseminated before post-partum day 180, having no more than 4-7 previous services, responded well to either Betadine or Septocid treatment.
Status:
Investigational
Source:
NCT01640808: Phase 3 Interventional Completed Hepatic Neoplasm Malignant Recurrent
(2012)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Peretinoin is an orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Peretinoin inhibits post-therapeutic recurrence of hepatocellular carcinoma via unclear mechanisms. The European Commission granted Orphan Drug designation for Kowa's peretinoin to treat hepatocellular carcinoma (HCC).
Status:
Investigational
Source:
INN:cinepazic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:cinametic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cinnamic acid is an odorless white crystalline acid that has only been recently studied for its potential in cancer prevention. Cinnamic acid and its derivatives are the major group of phenolic acids with ubiquitous distribution in fruits and vegetables. Preclinical data support the beneficial effects of Cinnamic acid, including antioxidant, anti-inflammatory, and anti-cancer activities. A more recent botanical review noted that cinnamic acid may help pre-diabetic and diabetic patients. When infected mice were fed food loaded with cinnamic acid, researchers saw that their insulin levels were better managed. Another study which used mice models saw that cinnamic acid improved glucose tolerance by promoting insulin secretion.