U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 33771 - 33780 of 34956 results

Status:
US Previously Marketed
Source:
Panparnit HCl by Geigy
(1949)
Source URL:
First approved in 1949
Source:
Panparnit HCl by Geigy
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Caramiphen is a muscarinic M1 acetylcholine receptor antagonist, which was used for the treatment of Parkinson Disease and cough, but then there using were discontinued. Caramiphen is also used in local anesthesia, and effect could be achieved through the suppression of voltage-gated Na⁺ currents.
Status:
US Previously Marketed
Source:
SURFACAINE by LILLY
(1961)
Source URL:
First approved in 1948
Source:
Surfacaine by Lilly
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Cyclomethycaine (also known as Surfacaine) is a local anesthetic.
Status:
US Previously Marketed
Source:
SURFACAINE by LILLY
(1961)
Source URL:
First approved in 1948
Source:
Surfacaine by Lilly
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Cyclomethycaine (also known as Surfacaine) is a local anesthetic.
Status:
US Previously Marketed
Source:
SURFACAINE by LILLY
(1961)
Source URL:
First approved in 1948
Source:
Surfacaine by Lilly
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Cyclomethycaine (also known as Surfacaine) is a local anesthetic.
Status:
US Previously Marketed
Source:
KECTIL DIHYDROSTREPTOMYCIN SULFATE by BRISTOL LABS
(1961)
Source URL:
First approved in 1948
Source:
Dihydrostreptomycin Sulfate by Merck
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Dihydrostreptomycin is an antibiotic compound derived from streptomycin by reduction with hydrogen. The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins, in addition it binds mechanosensitive channel of large conductance (MscL) and modifies its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell. It has about the same degree of antibacterial activity as streptomycin, but it is less effective against some gram-negative microorganisms. Because it has a higher risk of irreversible deafness, and its effectiveness is no greater that that of streptomycin, dihydrostreptomycin is no longer used clinically. To date dihydrostreptomycin is approved for veterinary use to treat bacterial infections.
Status:
US Previously Marketed
Source:
Octin HCl by Knoll
(1948)
Source URL:
First approved in 1948
Source:
Octin HCl by Knoll
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)



Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties. Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.
Status:
US Previously Marketed
Source:
THALAMYD by SCHERING
(1961)
Source URL:
First approved in 1948
Source:
Thalamyd by Schering
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Previously Marketed
Source:
Octin HCl by Knoll
(1948)
Source URL:
First approved in 1948
Source:
Octin HCl by Knoll
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties. Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.
Status:
US Previously Marketed
Source:
Octin HCl by Knoll
(1948)
Source URL:
First approved in 1948
Source:
Octin HCl by Knoll
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties. Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.
Status:
US Previously Marketed
Source:
Etamon Chloride by Parke-Davis
(1947)
Source URL:
First approved in 1947
Source:
Etamon Chloride by Parke-Davis
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. Tetraethylammonium blocks of apamin-sensitive and insensitive Ca2(+)-activated K+ channels. It is a weak agonist of the nicotinic receptor. Tetraethylammonium produces transient reductions in blood pressure. Tetraethylammonium hydroxide is used as a soluble source of hydroxide ions and in the synthesis of ionic organic compounds.

Showing 33771 - 33780 of 34956 results