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Restrict the search for
m amodiaquine
to a specific field?
Status:
Investigational
Source:
NCT00791570: Phase 1 Interventional Completed Neovascular Maculopathy
(2008)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04692181: Phase 1/Phase 2 Interventional Active, not recruiting Acute Graft-Versus-Host Reaction Following Bone Marrow Transplant
(2021)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04295538: Phase 2 Interventional Active, not recruiting Spinal Cord Injury (SCI)
(2020)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT00996255: Phase 1 Interventional Terminated Advanced/Metastatic Solid Tumors
(2006)
Source URL:
Class:
PROTEIN
Targets:
Conditions:
PHA-793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. PHA-793887 was cytotoxic for leukemic cell lines in vitro, with IC(50) ranging from 0.3 to 7 uM. In colony assays PHA-793887 showed very high activity against leukemia cell lines, with an IC(50) <0.1 uM indicating that it has efficient and prolonged antiproliferative activity. PHA-793887 induced cell-cycle arrest, inhibited Rb and nucleophosmin phosphorylation. PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo.
Class:
PROTEIN
Class:
PROTEIN
Status:
Investigational
Source:
NCT02957266: Phase 3 Interventional Unknown status Cervical Cancer
(2015)
Source URL:
Class:
PROTEIN
Status:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04666649: Phase 1 Interventional Active, not recruiting Relapsed or Refractory Acute Myeloid Leukemia
(2021)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04210245: Phase 2 Interventional Completed Compensated Cirrhosis
(2020)
Source URL:
Class:
PROTEIN
