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paritaprevir
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Status:
US Previously Marketed
Source:
VIEKIRA XR by ABBVIE
(2016)
Source URL:
First approved in 2014
Source:
VIEKIRA PAK (COPACKAGED) by ABBVIE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Paritaprevir is a potent inhibitor of the NS3/4A protease that rapidly and consistently suppresses HCV. Paritaprevir is metabolized by the Cytochrome P450 isoform 3A (CYP3A); therefore, ritonavir was used concurrently to increase plasma concentrations and to prolong the half-life of this agent allowing for once-daily dosing. Several antiviral regimens combining paritaprevir with other agents have shown impressive results, tolerable side effects, and importantly, provided support of ‘all-oral’ interferon-free regimens against HCV. Paritaprevir monotherapy is discontinued now but paritaprevir is used as a component of Viekira Pak and Technivie for the treatment of patients with genotype 1 chronic hepatitis C virus (HCV) infection.
