Search results for "Pharmacologic Substance[C1909]|Antineoplastic Agent[C274]|Topoisomerase-II Inhibitor" in comments (approximate match)
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Amonafide is an imide derivative of naphthalic acid. It is a novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. Amonafide retains cytotoxic activity even in the ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Elliptinium is an antineoplastic agent, which was used in the treatment of metastatic breast cancer in France under the name Celiptium. The drug is known to intercalate into DNA and inhibit topoisomerase II. Several studies have demonstrated that thi...