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1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine is the phospholipid, containing the saturated long-chain stearic acid inserted at the sn-1 and sn-2 positions, that used for the generation of micelles and liposomes. Polyethylene glycol (PEG)-modified 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine (DSPE–PEG), which forms sterically stabilized micelles, is widely used as a lipid-based nanocarrier for drug delivery PEG-DSPE block copolymers are biocompatible and amphiphilic polymers that can be utilized in the preparation of liposomes, polymeric nanoparticles, polymer hybrid nanoparticles, solid lipid nanoparticles, lipid-polymer hybrid nanoparticles, and microemulsions. Particularly, the terminal groups of PEG can be activated and linked to various targeting ligands, which can prolong the circulation time, improve the drug bioavailability, reduce undesirable side effects, and especially target specific cells, tissues, and even the intracellular localization in organelles.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
3-Tyrosine, in contrast to the para isomer, is readily racemized. The majority of the load was metabolized to m-hydroxyphenylacetic acid but m-hydroxymandelic acid and 3,4-dihydroxyphenylacetic acid were also detected. Low circulating levels of m-tyrosine in the plasma suggest that most of the load is held due to a first pass effect somewhere in the enterohepatic system and that this portion of the load is not in equilibrium with the plasma m-tyrosine. The metabolism of a m-tyrosine may give further insight into the deficiencies of the phenylalanine hydroxylating system found in the various phenotypes of phenylketonuria. 3-Tyrosine has been used experimentally as a substitute for L-DOPA in the treatment of Parkinsonism. 3-tyrosine mimics the action of Dopa in two experimental animal models. It was also obvious from the experiments with d,l- and l-m-tyrosine that only the l-isomer (3-Tyrosine) is active.
