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Restrict the search for
medroxyprogesterone acetate
to a specific field?
Status:
Possibly Marketed Outside US
Source:
NCT00613964: Phase 4 Interventional Terminated Heart Failure
(2009)
Source URL:
Class:
PROTEIN
Carperitide is a synthetic, recombinant atrial natriuretic peptide with both vasodilating and diuretic activity that was developed by Asubio Pharma and used in Japan for acute heart failure treatment. Although the current Japanese Society of Cardiology guidelines for treatment of acute heart failure (AHF) make a class IIa recommendation for Carperitide, a recent meta-analysis and retrospective study revealed that Carperitide could not improve survival rates and was rather associated with a more than double in-hospital mortality rate in patients with AHF.
Status:
Possibly Marketed Outside US
Source:
NCT00720902: Phase 4 Interventional Terminated Growth Hormone Deficiency
(2007)
Source URL:
Class:
PROTEIN
Somatorelin is 29 amino acid analogue of human growth hormone-releasing hormone used as a diagnostic agent for determining growth hormone deficiency. Growth-hormone-releasing hormone (GHRH, somatoliberin) is the hypothalamic peptide hormone that specifically stimulates synthesis and release of growth hormone (GH, somatotropin) by somatotrope cells of the anterior pituitary gland. The hypothalamic hormone growth hormone (GH)-releasing hormone (GHRH) acts on specific GHRH receptors (GHRH-R) in the anterior pituitary gland to stimulate the synthesis and secretion of GH and to promote somatotrope expansion. Somatorelin is applied to determine the somatotropic function of the anterior pituitary gland in cases of suspected growth hormone deficiency. The test distinguishes between pituitary and hypothalamic disorders but is not suitable as a screening test for growth hormone deficiencies. Somatorelin has been used in trials studying the treatment of Aging, Elderly, Sleep Disorders, Hormone Deficiency, and Mild Cognitive Impairment.
Status:
US Approved Rx
(2000)
First approved in 1994
Source:
BLA103936
Source URL:
Class:
POLYMER
Status:
US Approved Rx
(1977)
First approved in 1977
Class:
POLYMER
Status:
US Approved OTC
Source:
21 CFR 349.12(d)(4) ophthalmic:demulcents polysorbate 80
Source URL:
First approved in 1949
Class:
POLYMER
Conditions:
Polysorbate 80 is a nonionic surfactant and emulsifier often used in foods and cosmetics. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the manufacture of the popular antiarrhythmic amiodarone. Polysorbate 80 is also used as an excipient in some European and Canadian influenza vaccines. Influenza vaccines contain 25 μg of polysorbate 80 per dose. Polysorbate 80 is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb. In Europe and America, people eat about 100 mg of polysorbate 80 in foods per day on average. Polysorbate 80 has not been found to be carcinogenic. Rats fed with diets containing up to 5% polysorbate 80 by volume for 12 weeks showed no toxic effects.
Status:
Excipient
Class:
POLYMER
Status:
Excipient
Source:
9.2mg ORAL TABLET, EXTENDED RELEASE
Source URL:
Class:
POLYMER
Status:
Other
Class:
POLYMER
Status:
Other
Class:
POLYMER
Status:
Other
Class:
POLYMER
