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Restrict the search for
fludrocortisone acetate
to a specific field?
Status:
Investigational
Source:
NCT02383810: Phase 2 Interventional Completed Drug and/or Toxin-induced Diarrhea
(2015)
Source URL:
Class:
PROTEIN
Elsiglutide (ZP 1846) is a synthetic 39-amino acid glucagon-like peptide-2 (GLP-2) analogue. Upon subcutaneous administration, elsiglutide binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Elsiglutide prevents or reduces the occurrence of gastrointestinal damage caused by chemotherapeutic agents, including gastrointestinal mucositis and chemotherapy-induced diarrhea (CID). Elsiglutide is being developed by Helsinn Healthcare, for the prevention of chemotherapy-induced diarrhoea.
Status:
Investigational
Source:
INN:alrefimotide [INN]
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04462536: Phase 3 Interventional Completed Stroke, Acute
(2020)
Source URL:
Class:
PROTEIN
TAT-NR2B9C is a synthetic peptide fusion of the nine C-terminal residues of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor and the cell membrane protein transduction domain of the HIV-1 tat protein. It is a postsynaptic density protein-95 (PSD95) inhibitor with neuroprotective properties. It is under development for the treatment of acute stroke and acute cerebral ischemia.
Class:
PROTEIN
Anaritide (Auriculin-Registered Trademark) is a 25-amino-acid synthetic form of atrial natriuretic peptide. Scios Nova was developing anaritide acetate for use in the treatment, prevention and diagnosis of acute renal failure, heart failure and hypertension. Scios suspended development of AURICULIN® anaritide based upon the results of an interim analysis of data from a 250-patient Phase III study in oliguric acute renal failure. The study was suspended due to the low probability that a positive outcome could be obtained with respect to its primary clinical endpoint, dialysis-free survival.
Status:
Investigational
Source:
NCT04331080: Phase 2/Phase 3 Interventional Completed Mammoplasty
(2020)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03852719: Phase 3 Interventional Completed Chronic Hepatitis Delta
(2019)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03358355: Phase 1/Phase 2 Interventional Completed Peripheral Artery Disease
(2016)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03188848: Phase 1 Interventional Unknown status Healthy Subject
(2017)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04377126: Phase 2 Interventional Recruiting Peripheral Artery Disease
(2020)
Source URL:
Class:
PROTEIN
Lenomorelin (Ghrelin) is a pleiotropic hormone, whose effect on growth hormone secretion, through the growth hormone secretagogue (GHS) receptor, is one of its many actions. It is synthesized principally in the stomach. Ghrelin-producing cells constitute a distinct group of endocrine cells dispersed throughout the gastric mucosa and to a lesser extent in the small intestine and the endocrine pancreas. Ghrelin plasma levels rise during fasting and chronic caloric restriction to stimulate food intake and fat storage and to prevent life-threatening falls in blood glucose. Plasma ghrelin levels decrease after a meal is consumed and in conditions of energy surplus (such as obesity). Ghrelin has emerged as a key player in the regulation of appetite and energy homeostasis. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Ghrelin levels are negatively correlated with body mass index (BMI) and insulin resistance. Lenomorelin is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.
Status:
Investigational
Source:
NCT03578029: Phase 2 Interventional Terminated Junctional Epidermolysis Bullosa
(2019)
Source URL:
Class:
PROTEIN
