ELSIGLUTIDE

Description
Sources: https://adisinsight.springer.com/drugs/800027450 | https://patents.google.com/patent/US20160067311 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/elsiglutide

Elsiglutide (ZP 1846) is a synthetic 39-amino acid glucagon-like peptide-2 (GLP-2) analogue. Upon subcutaneous administration, elsiglutide binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Elsiglutide prevents or reduces the occurrence of gastrointestinal damage caused by chemotherapeutic agents, including gastrointestinal mucositis and chemotherapy-induced diarrhea (CID). Elsiglutide is being developed by Helsinn Healthcare, for the prevention of chemotherapy-induced diarrhoea.

Originator

Approval Year

Patents

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:55:18 UTC 2023` Edited by `admin` on `Sat Dec 16 14:55:18 UTC 2023`
Protein Sub Type
Record UNII	SC864Q40VB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ELSIGLUTIDE

Official Name

English

ZP1846

Code

English

L-LYSINAMIDE, L-HISTIDYLGLYCYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-SERYL-L-PHENYLALANYL-L-SERYL-L-SERYL-L-.ALPHA.-GLUTAMYL-L-LEUCYL-L-SERYL-L-THREONYL-L-ISOLEUCYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-ALANYL-L-LEUCYL-L-ALANYL-L-ALANYL-L-ARGINYL-L-.ALPHA.-ASPARTYL-L-PHENY

Systematic Name

English

Elsiglutide [WHO-DD]

Common Name

English

ZP-1846

Code

English

elsiglutide [INN]

Common Name

English

HIS-GLY-GLU-GLY-THR-PHE-SER-SER-GLU-LEU-SER-THR-ILE-LEU-ASP-ALA-LEU-ALA-ALA-ARG-ASP-PHE-ILE-ALA-TRP-LEU-ILE-ALA-THR-LYS-ILE-THR-ASP-LYS-LYS-LYS-LYS-LYS-LYS-NH2

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C266