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Restrict the search for
cortisone acetate
to a specific field?
Status:
Investigational
Source:
NCT01933256: Phase 1 Interventional Completed Type 2 Diabetes Mellitus
(2013)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT01396213: Phase 2 Interventional Completed Celiac Disease
(2011)
Source URL:
Class:
PROTEIN
N-(2-Bromophenyl)-9-Methyl-9-Azabicyclo[3.3.1]Nonan-3-Amine (also known as AT-1001) is a high-affinity and highly selective ligand at α3β4 nicotinic cholinergic receptors (nAChRs) that was reported to decrease nicotine self-administration in rats. AT-1001 has a single-digit nanomolar binding affinity for the α3β4 nAChR and over 100-fold selectivity over the α4β2 nAChR and α7 nAChR in competition binding experiments. In electrophysiological experiments, AT-1001 had partial agonist activity at the α3β4 nAChR, evoking 35% of maximum ACh response, and at the same doses, produced desensitization of the ACh response, effectively acting as a functional antagonist at the α3β4 nAChR. Interestingly, AT-1001 also selectively decreased self-administration of cigarette smoke extract (CSE), an aqueous extract of cigarette smoke components, without altering natural food intake, when administered systemically to rats trained to self-administer CSE
Status:
Investigational
Source:
NCT02383810: Phase 2 Interventional Completed Drug and/or Toxin-induced Diarrhea
(2015)
Source URL:
Class:
PROTEIN
Elsiglutide (ZP 1846) is a synthetic 39-amino acid glucagon-like peptide-2 (GLP-2) analogue. Upon subcutaneous administration, elsiglutide binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Elsiglutide prevents or reduces the occurrence of gastrointestinal damage caused by chemotherapeutic agents, including gastrointestinal mucositis and chemotherapy-induced diarrhea (CID). Elsiglutide is being developed by Helsinn Healthcare, for the prevention of chemotherapy-induced diarrhoea.
Status:
Investigational
Source:
INN:alrefimotide [INN]
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04462536: Phase 3 Interventional Completed Stroke, Acute
(2020)
Source URL:
Class:
PROTEIN
TAT-NR2B9C is a synthetic peptide fusion of the nine C-terminal residues of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor and the cell membrane protein transduction domain of the HIV-1 tat protein. It is a postsynaptic density protein-95 (PSD95) inhibitor with neuroprotective properties. It is under development for the treatment of acute stroke and acute cerebral ischemia.
Class:
PROTEIN
Anaritide (Auriculin-Registered Trademark) is a 25-amino-acid synthetic form of atrial natriuretic peptide. Scios Nova was developing anaritide acetate for use in the treatment, prevention and diagnosis of acute renal failure, heart failure and hypertension. Scios suspended development of AURICULIN® anaritide based upon the results of an interim analysis of data from a 250-patient Phase III study in oliguric acute renal failure. The study was suspended due to the low probability that a positive outcome could be obtained with respect to its primary clinical endpoint, dialysis-free survival.
Status:
Investigational
Source:
NCT04331080: Phase 2/Phase 3 Interventional Completed Mammoplasty
(2020)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03852719: Phase 3 Interventional Completed Chronic Hepatitis Delta
(2019)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03358355: Phase 1/Phase 2 Interventional Completed Peripheral Artery Disease
(2016)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03188848: Phase 1 Interventional Unknown status Healthy Subject
(2017)
Source URL:
Class:
PROTEIN
