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O-Methyl-Gambogic acid Methyl Ester (aka dimethyl-Gambogic acid) is a derivative of gambogic acid a naturally occurring compound found in the resin excreted by the garcinia hanburryi tree in Southeastern Asia. Dimethyl-Gambogic acid demonstrates antiapoptotic activity in T17 cells with an EC50 of 120 nM. It has also shown efficacy against the parasite Trypanosoma brucei with an IC50 of 1.3 micro-M.
