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Restrict the search for
sulfisoxazole acetyl
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Status:
Investigational
Source:
INN:tifuvirtide [INN]
Source URL:
Class:
PROTEIN
Tifuvirtide (also known as T 1249) is a synthetically designed hybrid retroviral envelope polypeptide patented by Trimeris, Inc. as fusion inhibitor useful for the treatment of HIV infection. Tifuvirtide binds to HIV glycoprotein 41 (gp41) and prevents its fusogenic conformation, inhibiting viral entry into host cells. Tifuvirtide is composed of sequences from HIV-1, HIV-2, and simian immunodeficiency virus. Tifuvirtide has greater potency in vitro, compared with enfuvirtide, and elicits activity against most enfuvirtide-resistant isolates in vitro and in vivo. A successful short-term phase 1/2 studies evaluation of antiretroviral activity and safety in humans proved the potential of this new drug, although further clinical development was discontinued.
Status:
Investigational
Source:
NCT03353350: Phase 3 Interventional Completed Type 2 Diabetes Mellitus
(2017)
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT03078400: Phase 1 Interventional Unknown status Ovarian Epithelial Cancer
(2017)
Source URL:
Class:
PROTEIN
Status:
Designated
Source:
EU-Orphan Drug:EU/3/14/1423
Source URL:
Class:
PROTEIN
ImMucin is a 21-mer long peptide therapeutic vaccine encoding the entire signal peptide (SP) domain of the MUC1 tumor-associated antigen, which is over expressed by most hematological tumors including multiple myeloma (MM). Preclinical studies of ImMucin and its internal epitopes in multiple myeloma suggested superior immunological and anti-tumor properties compared to other MUC1 TRA‐derived epitopes. ImMucin demonstrated encouraging short and long-term safety profile. Vaccination induced a remarkable anti-MM immune response. However, immunity was transient suggesting a need for boosting. Interestingly, durable disease stabilization was achieved in the third of the patients, continuing despite the loss of immune response in peripheral blood. Moreover, the encouraging responses to subsequent therapies employed at clinical progression, suggest this novel approach to be potentially valuable in the setting of maintenance and/or early biochemical progression.
