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Restrict the search for
prilocaine
to a specific field?
Status:
Possibly Marketed Outside US
Source:
M021
(2020)
Source URL:
First approved in 2020
Source:
M021
Source URL:
Class:
PROTEIN
Status:
US Approved Rx
(2003)
Source:
ANDA076453
(2003)
Source URL:
First approved in 1965
Source:
NDA021383
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Prilocaine is a local anesthetic that is similar pharmacologically to lidocaine. Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns. Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Currently, Prilocaine is used most often for infiltration anesthesia in dentistry.
