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Restrict the search for
paliperidone palmitate
to a specific field?
Status:
Investigational
Source:
NCT02561000: Phase 2 Interventional Completed Arterial Occlusive Diseases
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
PZ-128 (also known as P1pal7 ) is a cell-penetrating pepducin inhibitor of PAR1 that targets the receptor-G-protein interface on the inside surface of platelets. In preclinical studies, PZ-128 suppresses PAR1 aggregation and arterial thrombosis in guinea pigs and baboons and strongly synergized with oral clopidogrel. PZ-128 shows potent anti-metastatic and anti-angiogenic activity in Breast, Ovarian, and Lung Cancer preclinical studies. In clinical trials, PZ-128 shows a promising antiplatelet activity that provides rapid, specific, dose-dependent, and reversible inhibition of platelet protease-activated receptor-1 through a novel intracellular mechanism.
Status:
Investigational
Source:
NCT03748758: Phase 1 Interventional Completed Healthy Adult Volunteers
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Excipient
Source:
0.09%w/v INFILTRATION INJECTABLE, LIPOSOMAL
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
DIPALMITOYLPHOSPHATIDYLGLYCEROL (DPPG) is a phosphatidylglycerol in which the phosphatidyl acyl groups are both palmitoyl. DPPG is one of the commonly used lipids in liposome studies and biological systems research.
Status:
Designated
Source:
FDA ORPHAN DRUG:640618
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
