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Restrict the search for
lamivudine
to a specific field?
Status:
Investigational
Source:
NCT04668235: Phase 3 Interventional Completed COVID-19
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
(+)-cis-Lamivudine is an enantiomer of lamivudine, considered to be impurity. Lamivudine is a reverse transcriptase inhibitor used alone or in combination with other classes of anti-human immunodeficiency virus (HIV) drugs in the treatment of HIV infection.
Status:
US Previously Marketed
Source:
STAVUDINE; LAMIVUDINE by PHARMACARE LTD
(2009)
Source URL:
First approved in 1994
Source:
ZERIT by BRISTOL
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Stavudine is used for the treatment of human immunovirus (HIV) infections. Stavudine is sold under the brand name Zerit among others.
