U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 11 - 20 of 467 results

Status:
Investigational
Source:
INN:larotaxel [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:

LAROTAXEL is a taxoid with potential antineoplastic activity. It prevents microtubule depolymerization, thereby inhibiting cell proliferation. It displays a broad spectrum of antitumor activity in vitro and in vivo, including activity against P-glycoprotein expressing tumors. LAROTAXEL was in phase III clinical trials for the treatment of breast cancer, pancreatic cancer, and bladder cancer. However, its development was discontinued.
Status:
Investigational
Source:
INN:flurantel
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Flurantel is an anthelmintic agent. Information about the current use of this compound is not available.
Status:
Investigational
Source:
USAN:RALANITEN ACETATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT04249336: Phase 3 Interventional Completed Dentin Hypersensitivity
(2019)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
J Anim Physiol Anim Nutr (Berl). Jun 2016;100(3):520-5.: Not Applicable Veterinary clinical trial Completed N/A
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. Following ingestion, T-2 toxin causes acute and chronic toxicity and induces apoptosis in the immune system and fetal tissues. T-2 toxin is usually metabolized and eliminated after ingestion, yielding more than 20 metabolites. Consequently, there is a possibility of human consumption of animal products contaminated with T-2 toxin and its metabolites. The molecular mechanism of inhibition of protein synthesis may be the high affinity of T-2 toxin for the 60S ribosomal subunit.
Status:
Investigational
Source:
Chemioterapia. Jun 1987;6(2 Suppl):706-8.: Not Applicable Human clinical trial Completed Lung Neoplasms/therapy
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:stevaladil
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Stevaladil is a pregnanediol derivative patented by Shionogi & Co., Ltd. as antiparasitic agent
Status:
Investigational
Source:
USAN:Acetiamine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Acetiamine (syn. thianeurone or diacetamine) is a thiamine derivative which is rarely used in pharmaceuticals. It is lipid-soluble. It has been studied for the treatment of rheumatic diseases.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Showing 11 - 20 of 467 results