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Restrict the search for
conivaptan
to a specific field?
Status:
US Approved Rx
(2007)
Source:
NDA022016
(2007)
Source URL:
First approved in 2005
Source:
NDA021697
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conivaptan is an arginine vasopressin (AVP) receptor antagonist with affinity for AVP receptor subtypes V1A and V2. The antidiuretic action of AVP is mediated through activation of the V2 receptor, which functions to regulate water and electrolyte balance at the level of the collecting ducts in the kidney. Conivaptan was approved in 2004 for hyponatremia caused by syndrome of inappropriate antidiuretic hormone. Conicaptan is being evaluated for reduce intracranial pressure in patients with traumatic brain injury, and as a treatment for heart failure.
