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Restrict the search for
bupropion
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Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Bupropion is an atypical antidepressant that also has usefulness as a smoking-cessation aid. Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute to its antidepressant activity, this metabolite may also contribute to the smoking-cessation properties of bupropion. Compared to bupropion hydroxybupropion inhibit norepinephrine (NE) uptake with similar potency. The effects of bupropion and enantiomers of hydroxybupropion on human nAChR subtypes indicate that the (2S,3S) isomer is more potent than the (2S,3R) isomer or racemic bupropion as an antagonist of alpha(4)beta(2) subtypes of nicotinic acetylcholine receptor (nAChR). In addition, both isomers of hydroxybupropion possess weaker antagonist activity to the alpha3/beta4 and alpha4/beta4 subtypes of nAChR.
