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Restrict the search for
aminoglutethimide
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(R)-Aminoglutethimide is R-isomer of racemate anti-steroid drug Aminoglutethimide, marketed by Novartis for the treatment of Cushing syndrome and other conditions. (R)-Aminoglutethimide was shown to more active than (S)-isomer in inhibiting corticosteroid release in rats, more potent in inhibiting aromatization of testosterone by human placental microsomes. (R)-Aminoglutethimide was investigated in a clinical trial against breast cancer, where it was found to enhance the clearance rate of plasma estrone sulfate.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(S)-Aminoglutethimide is S-isomer of racemate anti-steroid drug Aminoglutethimide, marketed by Novartis for the treatment of Cushing syndrome and other conditions. (S)-Aminoglutethimide was shown to less active than (R)-isomer in inhibiting corticosteroid release in rats, less potent in inhibiting aromatization of testosterone by human placental microsomes.
