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m momelotinib
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Gamabufotalin belongs to bufadienolides was first isolated from B. formosus Boulenger and described by Kotake in 1928. Gamabufotalin is a component of traditional Chinese medicinal preparations containing ChanSu, also known as toad venom, a dried product of the skin and parotid venom glands from the Asiatic toad (Bufo gargarizans).
Gamabufotalin inhibits sodium/potassium-transporting ATPase activity and exhibited positive inotropic action in the papillary muscle preparations. Gamabufotalin demonstrates significant anti-tumor activity in vitro on cancer cells and in vivo on mouse tumor xenografts. Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis.
