U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 171 - 180 of 229 results

Status:
Investigational
Source:
NCT00003847: Phase 2 Interventional Terminated Lung Cancer
(1998)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Biricodar (also known as VX-710) was developed by Vertex as a chemosensitizing agent designed to restore the effectiveness of chemotherapeutic agents in tumor multidrug resistance. The phase II trials had commenced for biricodar, in combination with chemotherapy, for five common cancer indications: breast, ovarian, soft-tissue sarcomas, small cell lung cancer, and prostate cancer. In spite of completed trials, development of biricodar was discontinued because of the adverse effects.
Status:
Investigational
Source:
NCT04614337: Phase 2 Interventional Completed Growth Hormone Deficiency
(2020)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Ibutamoren (L-163,191 MK-0677) is a spiropiperidine agonist of the ghrelin receptor and a growth hormone secretagogue. Ibutamoren mimics the actions of growth hormone releasing peptide-6 to increase serum levels of serum insulin-like growth factor-I (IGF-I). Orally active Ibutamoren was being developed by Merck & Co. for a variety of indications, including fibromyalgia, muscle wasting/weakness in patients with chronic kidney disease, Alzheimer's disease and fractures.However, there has been no recent development reported or development has been discontinued for these indications.
Status:
Investigational
Source:
INN:moxilubant [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Moxilubant is an orally active leukotriene B4 antagonist patented by Ciba-Geigy A.-G. and studied for psoriasis, rheumatoid arthritis, and chronic obstructive pulmonary disease treatment. Moxilubant inhibits LTB4 signaling with a potency of 2–4 nM. In a phase 1 study in 10 healthy volunteers, Moxilubant was administered orally once or twice daily for 7 days at doses ranging from 100 to 500 mg. At dose levels of 150 mg and above, LTB4 pathway inhibition reached at least 75%. At doses of 300 mg and above, pathway inhibition reached 100%. A Phase 2 study was conducted in 24 patients with COPD treated with 240 mg/day Moxilubant for 4 weeks. In this study, there were no changes in sputum cell counts or biomarkers or in spirometry measures, even though plasma levels of Moxilubant were sufficient to significantly reduce pathway signaling.
Status:
Investigational
Source:
INN:roxifiban
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Roxifiban (also known as DMP754), a potent antiplatelet agent in inhibiting platelet aggregation, and has a high specificity and affinity for human platelet glycoprotein IIb/IIIa complex (GPIIb/IIIa) receptors. Roxifiban participated in clinical trials phase III for the treatment of peripheral arterial disorders. This drug was also well tolerated in patients with chronic stable angina pectoris and was studied in the treatment of heparin-induced thrombocytopenia, and thrombosis. However, the development of this drug appears to have been discontinued.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cupric perchlorate is a catalyst used in organic synthesis, for example, for the cyanosilylation of aldehydes and diacetylation, for acetylation of heteroatoms etc.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There are no information about AMMONIUM COBALTOUS PHOSPHATE, except is mentioned, that it was toxic.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Dibasic lead phosphite is slight white, sweet and toxic ionic compound. Dibasic lead phosphite can dissolve in hydrochloric acid, and nitric acid, but not in water. Dibasic lead phosphite is antioxidant; it has the excellent performance of resistance to ultraviolet ray, cold, and ageing. Mainly used for the heat stabilizer of Polyvinyl Chloride opaque products because of good insulation, weatherablity and ultraviolet radiation absorbency.

Showing 171 - 180 of 229 results