ROXIFIBAN ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H29N5O6.C2H4O2
Molecular Weight	507.5368
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)=O.CCCCOC(=O)N[C@@H](CNC(=O)C[C@H]1CC(=NO1)C2=CC=C(C=C2)C(N)=N)C(=O)OC

InChI

InChIKey=WDEMHBVIYZGQCD-KALLACGZSA-N

InChI=1S/C21H29N5O6.C2H4O2/c1-3-4-9-31-21(29)25-17(20(28)30-2)12-24-18(27)11-15-10-16(26-32-15)13-5-7-14(8-6-13)19(22)23;1-2(3)4/h5-8,15,17H,3-4,9-12H2,1-2H3,(H3,22,23)(H,24,27)(H,25,29);1H3,(H,3,4)/t15-,17+;/m1./s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8970768 | https://www.ncbi.nlm.nih.gov/pubmed/14727937 | https://www.ncbi.nlm.nih.gov/pubmed/11904529 | https://adisinsight.springer.com/drugs/800006832

Roxifiban (also known as DMP754), a potent antiplatelet agent in inhibiting platelet aggregation, and has a high specificity and affinity for human platelet glycoprotein IIb/IIIa complex (GPIIb/IIIa) receptors. Roxifiban participated in clinical trials phase III for the treatment of peripheral arterial disorders. This drug was also well tolerated in patients with chronic stable angina pectoris and was studied in the treatment of heparin-induced thrombocytopenia, and thrombosis. However, the development of this drug appears to have been discontinued.

Approval Year

PubMed

Title	Date	PubMed
Oral antiplatelet efficacy of the platelet GPIIb/IIIa antagonist, DMP754 in non-human primates.	1998 Mar 1	9645915

Patents

Sample Use Guides

In Vivo Use Guide

Ninety-eight patients were randomized to receive either a placebo or 1 of 8 oral dosages of roxifiban. Twenty-two patients were enrolled in multiple-dose regimens, bringing the total study population to 120. The oral dosages were 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, or 2.5 mg/day for up to 30 days.

Route of Administration: Oral

Name

Type

Language

ROXIFIBAN ACETATE

Official Name

English

ROXIFIBAN ACETATE [USAN]

Common Name

English

Roxifiban acetate [WHO-DD]

Common Name

English

DMP 754

Code

English

DMP-754

Code

English

(2S)-3-(2-((5R)-3-(P-AMIDINOPHENYL)-2-ISOXAZOLIN-5-YL)ACETAMIDO)-2-(CARBOXYAMINO)PROPIONIC ACID, 2-BUTYL METHYL ESTER, MONOACETATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1327