U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 161 - 170 of 196 results

structurally diverse
Status:
US Previously Marketed
Source:
Black Mustard U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Black Mustard U.S.P.
Source URL:

Class:
STRUCTURALLY DIVERSE

structurally diverse
Status:
Possibly Marketed Outside US

Class:
STRUCTURALLY DIVERSE

structurally diverse
Status:
Possibly Marketed Outside US

Class:
STRUCTURALLY DIVERSE

structurally diverse
Status:
Possibly Marketed Outside US
Source:
Canada:SINAPIS ARVENSIS, FLOS
Source URL:

Class:
STRUCTURALLY DIVERSE

structurally diverse
Status:
Possibly Marketed Outside US
Source:
Canada:BUNIAS ORIENTALIS
Source URL:

Class:
STRUCTURALLY DIVERSE

Status:
First approved in 1987

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Glufosamide (glucosylifosfamide mustars) consists of iphosphoramide mustard conjugated to glucose, and is an alkylating agent (affecting the ability of the cancer cell to multiply by causing breakage of the DNA strands). Glufosamide is considered a targeted chemotherapy with fewer side effects than alternative chemotherapies. Its specific mode of action on normal and pathological cells is still under investigation. Glufosamide was studied for use in several cancers, like pancreatic and prostate cancer, and head and neck squamous cell carcinoma. Multipe clinical trials have been completed or are still ongoing. Most promising results were found when glufosamide was used in combination treatments, rather than alone.
Status:
First approved in 1964

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which produces a number of DNA adducts with the DNA interstrand crosslink (ICL) considered to be the critical cytotoxic lesion. Melphalan is used to treat different cancers including myeloma, melanoma and ovarian cancer.

Showing 161 - 170 of 196 results