Isosafrole, a stiripentol analog, is a potent LDH inhibitor. Stiripentol is a new-generation antiepileptic drug, and its chemical structure is unrelated to other antiepileptic drugs. Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), which is a component of the astrocyte-neuron lactate shuttle. Isosafrole is a substructure of stiripentol that lacks the hydroxyl group and tertiary-butyl group of stiripentol. Isosafrole strongly inhibited the pyruvate-to-lactate conversion by both LDH1 and LDH5, suggesting that it inhibits lactate production itself. Isosafrole suppresses seizures in vivo. Going by the lactate reduction by ketogenic diets, LDH inhibitors for the pyruvate-to-lactate conversion, such as isosafrole, would be more effective for antiepileptic actions. Isosafrole is a known inducer of some of the liver enzymes of the cytochrome P-450 group in rodents, especially CYP1A2.

There is no information about biological nor medical application of ferrous selenide (also known as iron selenide). But is used in electrical semiconductors.

Piperidine is a normal constituent in mammalian brain. It was shown to affect synaptic mechanism in the CNS, and influence neural mechanisms governing regulation of emotional behavior, sleeping, and extrapyramidal function. In addition, there are enzyme systems within the brain that synthesize and metabolize piperidine, and uptake and storage mechanisms for piperidine are found in the nerve endings. Piperidine, which proved to be a highly effective “antipsychotomimetic” agent in rats, has been reported to bring about substantial improvement in a variety of schizophrenic patients.

Nickel nitrate, a water soluble salt of Ni is irritating to the eyes, skin and, upon inhalation of the dust, respiratory tract. It may cause skin allergy. Nickel nitrate is a carcinogen, along with most other nickel compounds. The nickel ion is also toxic to aquatic organisms.

Dicazepam (known as Ro5-3448, chlorodiazepam and 2'-chloro-diazepam) is a 2’-chloro derivative of diazepam that has emerged as a designer drug and is intended for forensic and research applications. It is metabolized in vivo into the pharmacologically active which can be detected in urine.

There is no information about biological and pharmacological application of lead stearate. But is known, that this is a toxic substance which can accumulate inside organism, because it can be absorbed through the skin.