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Restrict the search for
sulfisoxazole acetyl
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
K-858 is a small molecule inhibitor of Eg5 (kinesin spindle protein), a mitotic kinesin that plays an essential role in establishing mitotic spindle bipolarity. K-858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. K858 induces mitotic arrest, apoptosis, and cell growth inhibition in cancer cells. K-858 exhibited potent antitumor activity in xenograft models of cancer, and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.
