Conduritol B epoxide is an inhibitor of mammalian glucocerebrosidase and lowers glucosylceramide degradation. Glucosylceramide is the precursor for all of the more complex glycosphingolipids. The experiments on animals were shown, that conduritol B epoxide preserved ganglioside distribution at the neuromuscular junction, delayed disease onset, improved motor function and preserved motor neurons as well as neuromuscular junctions from degeneration. In addition, conduritol B epoxide mitigated gene dysregulation in the spinal cord and restored the expression of genes involved in signal transduction and axonal elongation.