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Search results for m root_references_citation in Reference Text / Citation (approximate match)
Status:
Investigational
Source:
NCT03094169: Phase 1/Phase 2 Interventional Terminated Solid Tumor, Adult
(2017)
Source URL:
Class:
CONCEPT
Status:
Investigational
Source:
NCT03801915: Phase 2 Interventional Completed Colon Cancer
(2019)
Source URL:
Class:
CONCEPT
Status:
Investigational
Source:
NCT03118349: Phase 1 Interventional Terminated Pancreatic Carcinoma
(2017)
Source URL:
Class:
CONCEPT
Status:
Other
Class:
CONCEPT
Status:
Other
Class:
CONCEPT
Status:
Other
Class:
CONCEPT
Status:
Other
Class:
CONCEPT
Status:
Other
Class:
CONCEPT
Status:
Other
Class:
CONCEPT
Status:
US Approved Rx
(2018)
Source:
NDA209299
(2018)
Source URL:
First approved in 2018
Source:
NDA209299
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Fostamatinib is a pro-drug of a Syk inhibitor R406 initially developed by Rigel Pharmaceuticals, but then in-licensed by AstraZeneca. It reached phase III of clinical trials for such diseases as Rheumatoid Arthritis and Immune Thrombocytopenic Purpura, however, AstraZeneca decided not to proceed with regulatory filings and return the rights to the compound to Rigel Pharmaceuticals. In 2018 the drug was approved by the FDA for treatment of chronic immune thrombocytopenia. Fostamatinib is being developed for Autoimmune Hemolytic Anemia (phase II), graft versus host disease (phase I) and ovarian cancer (phase I).
