NC-410

Approval Year

Substance Class	Concept
Record UNII	I8YLE03D8B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NC-410

Code

English

NC410

Code

English

NC 410 [WHO-DD]

Common Name

English

LAIR-2 IGG1 FC FUSION PROTEIN

Common Name

English

NC410, HUMAN LEUKOCYTE-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR-2 (LAIR-2) PROTEIN FUSED TO HUMAN IGG1 FC DOMAIN

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C173559

Created by admin on Sat Dec 16 15:25:56 GMT 2023 , Edited by admin on Sat Dec 16 15:25:56 GMT 2023

PRIMARY

FDA UNII

I8YLE03D8B

Created by admin on Sat Dec 16 15:25:56 GMT 2023 , Edited by admin on Sat Dec 16 15:25:56 GMT 2023

PRIMARY

This is a non-substance concept

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LEUKOCYTE-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR 1

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Comments:

Acts as a decoy receptor by binding collagen with higher affinity than LAIR-1 prevent immune evasion from collage interacting with LAIR-1 expressed on immune cells,

Amount:

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					I8YLE03D8B

NC-410

ACTIVE MOIETY

Comments:

NC410 binds to LAIR-1 ligands including collagen, C1q, MBL and SP-D with high avidity and this binding blocks the interaction of soluble and cell surface LAIR-1 to its ligands.

Amount: